Medication Comparison

TreatmentMethodsTitle

If you have toenail fungus, there are three treatment options to consider: number 1: Surgical Removal: a specialist can surgically remove the nail and the fungus below. This is expensive, painful and invasive, but highly effective. Number 2: Oral Medication: prescription pills are available which can address nail fungus. These medications are not 100% effective and involve some risk of liver damage. Number 3: Topical Treatment: A variety of topical creams exist which are marketed to treat toenail fungus. Only a small number of formulations have been found effective, but if the correct product is chosen this is by far the safest and least invasive form of toenail fungus treatment.

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There are three methods to treating toenail fungus Surgical Removal
surgical treatment for toenail fungus
Oral Medication
Oral RX for Nail Fungus
Topical Treatment
Topical Toenail Fungus Treatment

TOP 5 TOPICAL NAIL FUNGUS TREATMENTS (2017):

Below are the top rated over-the-counter topical nail fungus treatments on market – each has been thoroughly evaluated by our editors, health professionals, and fellow Nail Fungus sufferers. All of the following treatments are topical solutions to Nail Fungus. The chart at the bottom of this page explains the advantages of Topical medication over Oral and Surgical options.

 EmoniNail™
Rank 1 - EmoniNail
Funginix
Rank 2 - Funginix
Zetaclear
Rank 3 Zetaclear
Naturasil
Rank 4 - Dermisil
Nail Rx
Rank 5 Nail RX
1. Treatment Rating99.5 / 10089.7 / 10086.5 / 10080.1 / 10078.4 / 100
2. Customer Rating5 Star Nail Fungus Product4 Star Nail Fungus Product3.5 Star Nail Fungus Product3 Star Nail Fungus Product3 Star Nail Fungus Product
3. Editor Review
4. MSRP$59.95
Visit Official Site
$59.95$49.95$35.95$49.95
5. Patients Treated (est.)20,000+20,000+20,000+10,000 - 20,00010,000 - 20,000
6. Success Rate*89.4%83.2%76.1%71.1%68%
7. Treatment TimeShortest (1-2 Months)Average (2-4 Months)Average (2-4 Months)Average (2-4 Months)Long (3-6 Months)
8. Product Safety Safe to UseSafe to UseSafe to UseSafe to UseSafe to Use
9. Return PolicyRisk FreeRestock FeeRisk FreeRisk FreeUnknown
10. Customer Support5 Star Nail Fungus Product3 Star Nail Fungus Product4 Star Nail Fungus Product4 Star Nail Fungus Product4 Star Nail Fungus Product

If your nails are infected with Nail Fungus there are two actions you must now take: (1) Find treatment and (2) understand how to use that treatment. Our Treatment Guide provides step-by-step instructions for achieving maximum effectiveness with topical treatments.

Review of Our Top Pick Topical (OTC) Nail Fungus Treatment

EmoniNail RANK: #1
Rank 1 - EmoniNail Review Summary
Top Pick Badge
EmoniNail is our top-most recommended product for the topical treatment of fingernail and toenail fungus. The superior blend of proven ingredients make EmoniNail an effective* formula to dramatically improve the vitality and appearance of the nail bed and surrounding skin.The formulation, which was last updated in 2016 combines a powerful anti-fungal active ingredient with nail penetrating essential oils which can result* in superior effectiveness in the treatment of nail fungus. This conclusion of superiority is supported by our customer reviews and an overall success rate higher than any other product on the market.
Nail-Fungus-Users-Choice
Our experts agree that the EmoniNail treatment formulation is the ideal combination.Users consistently observe a reduction of redness, pain, and irritation within weeks*. Within months the average users sees complete removal of visible nail fungus. The vast majority (95%+) of users experience regrowth of clear, revitalized, fungal-free nails*. We recommend EmoniNail in conjunction with diligent adherence to our treatment guide for maximum effectiveness.Active Ingredient: Undecylenic Acid, 10%Means of Nail Penetration: Tea Tree Oil

 

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*Based on aggregated user reviews. Not a scientific study of product efficacy. Individual results may vary.

Top 30 Topical (OTC) Nail Fungus Products (2017)

RankProductTreatment RatingEditor ReviewPatients Treated (est.)Success Rate*Rank ChangeMSRP
1EmoniNail
Rank 1 - EmoniNail
99.5 / 10020,000+89.2%+1$59.95
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2Funginix (Fungisil)
Rank 2 - Funginix
89.7 / 10020,000+83.2%-1$59.95
3Zetaclear
Rank 2 Zetaclear
86.5 / 10020,000+76.1%+1$49.95
4Dermisil
Rank 4 - Dermisil
80.1 / 10010,000 - 20,00071.1%-1$29.95
5Nail Rx
Rank 5 Nail RX
78.4 / 10010,000 - 20,00068%0$39.95
6Pedifix Fungasoap71.1 / 10010,000 - 20,00067%-3$49.95
7Opi Fungus Fix69.6 / 10010,000 - 20,00066%0$44.95
8Omega Labs Fungus Treatment68.1 / 10010,000 - 20,00065%0$34.95
9Fungi Nail Brand67.9 / 10010,000 - 20,00056.4%0$25.95
10Excilor65.7 / 10010,000 - 20,00052%0$21.95
11Dr G.63.4 / 1005,000 - 10,00049%0$29.95
12Claripro60.9 / 1005,000 - 10,00047%0$29.95
13Blue Goo59.8 / 1005,000 - 10,00047%+1$9.95
14Amoresse Thymol57.4 / 1005,000 - 10,00044%0$29.95
15Good N Natural Nail Fungus56.1 / 1005,000 - 10,00043%+2$15.99
16Keractil55.4 / 1005,000 - 10,00039%0$19.95
17Mycocide54.3 / 1005,000 - 10,00038%0$9.95
18Pedi-Cure50.8 / 1001,000 - 5,00038%0n/a
19Barielle Fungus RX49.7 / 1001,000 - 5,00037%+1$15.95
20OPI Fungus Fix (2003 Formula)49.1 / 1001,000 - 5,00036%0$19.95
21FungaSoap (Original Formula)48.9 / 1001,000 - 5,00035%0$8.14
22Saprox48.2 / 1001,000 - 5,00035%0$42.90
23Deggurcide47.2 / 1001,000 - 5,00034%0$39.95
24Anidulafungin (Eraxis)46.3 / 1001,000 - 5,00033%0$49.95
25Nail Tek45.1 / 1001,000 - 5,00032%0$8.40
26PurNail43.5 / 100< 1,00031.2%-5$54.95
27Lamisil Terbinafine42.1 / 100< 1,00030.9%0$12.95
28Varisi41.3 / 100< 1,00029.9%0$9.95
29Tineacide40.4 / 100< 1,00033.3%0$15.36
30Tammy Taylor Thymolize39.6 / 100< 1,00032%+1$13.23
31Radiant Health38.5 / 100< 1,00032%-1$19.95

*Based on aggregated reviews. Not a scientific study of success rate

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Complete List of Finger and Toenail Fungus Treatment Types

Topical Prescription Drugs which are used to Fight Fungal Infections of the Nails

Topical prescription remedies may be used alone or with oral agents. One benefit of using topical remedies is that the medication may be applied directly to infected areas. The risk of systemic complications due to side effects is reduced. Theoretically, more medicine should get directly to the area which needs treatment.

A down side of using topical preparations is that more time may be needed for administration when compared with the amount of time required to take oral drugs. Unless topical remedies are well formulated, many of the healing properties may not be available, as absorption into the nails and surrounding tissues may be poor. Topical remedies are more likely to cause localized irritation than oral remedies do. It may be more difficult to use a topical remedy on your toenails if you have mobility issues. The cost of prescription treatments may be prohibitive.

The following charts compare the benefits and shortcomings of currently available FDA approved oral medications which are used to treat fungal infections of the nails.

Generic NameBrand NamesAverage Monthly CostHow UsedBenefitsPrecautions and Potential Side Effects
Tavaborole
Kerydin
$1265.00 for a 10mL. BottleApplied directly to the toenails daily for 48 weeks.Serious negative reactions are rare.Seek medical assistance if you experience: swelling of the face or throat, difficulty breathing, or hives.

Irritation, redness, itching, swelling, or peeling of the tissues surrounding the treated nail may occur. Ingrown toenails may develop.

Promptly wipe the medication off of your skin if it gets on it. Do not apply medication to any tissues except affected nails.

The medication is flammable.
Efinaconazole
Jublia
$468.00 for 4 mLApply to the infected nail and surrounding skin daily for 48 weeks.Serious negative reactions to the medication are rare.Seek medical assistance if you experience: swelling of the face or throat, difficulty breathing, hives, irritation or pain at the application site, blisters, or if you develop an ingrown toenail.

It is unknown if this medication passes into breast milk. Avoid use during pregnancy or while breastfeeding.

The medication is flammable.
Ciclopirox
Penlac
$930.00 for Penlac brand 6.6 mL

$30.00 for generic, 6.6mL
Apply this nail lacquer directly to the nails every day. Do not wash the area for at least 8 hours. Use alcohol to remove the medication from your nails.
The medication may need to be used for 48 weeks to be fully effective.
Serious negative reactions to the medication are rare.
Reduces the rate of reinfection by 70%
Seek medical assistance if you experience: swelling of the face or throat, difficulty breathing, hives, irritation or pain at the application site, blisters, or if you develop an ingrown toenail.

It is unknown if this medication passes into breast milk. Avoid use while breastfeeding.
The medication is flammable.

Cure rate to get rid of infection is only 7%

Notify your doctor of all medications which you take. Be sure that he or she knows your complete health history. This is especially important if you have been diagnosed with a seizure disorder, diabetes or an immune problem.

Oral Prescription Medications which are Used to Treat Fungal Infections of the Nails

If you choose to take an oral medication to treat your nail fungus; there are several agents for your health care provider and you to choose from. The success rates of oral medications which are used to treat nail infections are approximately fifty percent. Even if the infection is deemed “cured”, it usually recurs in between two and five out of ten people. (Del Rosso, 2014) Oral medications are generally easier to use than topical remedies. They are more likely to cause detrimental side effects than topical agents.

Almost all of the oral agents possess potential side effects which can only be described as very dangerous and potentially life threatening. If you choose to use an oral agent, be sure that you and your doctor discuss your health history and current medications in detail. It is essential that you weigh the risks of treatment carefully with the potential benefits. While nail fungus is not life threatening, nor does it cause serious illness; the drugs which are used to treat the condition may cause serious illnesses or in rare cases, deafness or death. If you have underlying health issues, are pregnant, want to become pregnant or are breastfeeding it is critically important that you learn everything you can about the treatment before starting an oral medication as the drugs may cause harm to your baby.

The following charts compare the benefits and shortcomings of currently available FDA approved oral medications which are used to treat fungal infections of the nails.

Generic NameBrand NamesAverage Monthly CostHow UsedBenefitsPrecautions and Potential Side Effects
GriseofulvinFulvicin, Gifulvin, Gris-Peg Brand name $240.00/ 30 500mg.tablet

Generic $180.00/ 30 500mg. tablets
Take the medication by mouth on a daily basis. It must be taken for up to one year to resolve infections of the nails. Treats discoloration of nails.Not recommended for use if liver disease, lupus, or porphyria is present.

Does not work well for fungal infections of the nails.

Seek medical assistance if you experience: swelling of the face or throat, difficulty breathing, hives, numbness or tingling of the extremities, changes in mood, confusion, sunburn-like rash, hearing changes, butterfly-shaped facial rash, joint or muscle pain. Notify your doctor if these side effects occur: yellowing of the skin or eyes, abdominal pain, persistent nausea or vomiting, changes in urination, fever, or sore throat.

Prolonged use of this medication may encourage the development yeast infections of the mouth and vagina.

Do not use if you are pregnant, may become pregnant, or are nursing. May damage an unborn baby. Males should avoid impregnating a female. It is unknown if the medication continues to affect sperm after use is discontinued.

Avoid alcohol and limit sun exposure.

A complete blood count, liver, and kidney function tests must be performed periodically during treatment.
Terbinafine Lamisil Lamisil brand (30) 250 mg. tablets $700.00

Generic (30) 250 mg. tablets $6.00
Dosing regimen variesFew side effects. 35-50% cure rate for fungal infections of the nails.

Inexpensive if generic drug is used.
May cause gastrointestinal distress and be harmful for individuals who have liver disease. Abnormalities of the liver enzymes, drug-induced hepatitis and drug interactions are less frequent compared to itraconazole. (Leelavathi, 2014)

Changes in the sense of taste may occur. Limit alcohol consumption and sun exposure while taking.

Use during pregnancy and while breastfeeding is not recommended.

Seek medical help if the following occur: fever, sore throat, swollen glands, mouth sores, blood in urine, dark colored urine, chest pain, irregular heartbeat, hives, shortness of breath, severe abdominal pain, nausea or vomiting which does not go away, yellowing of the eyes or skin, or loss of appetite.
IitraconazoleSporanoxBrand name: (60) 100 mg. capsules $1380.00

Generic (60) 100 mg. capsules $380.00
Dosing schedules may vary. Usually taken twice daily. Sometimes used for pulse, intermittent, dosing. Take the medication on a full stomach. Do not take at the same time as antacids.

Take with a cola beverage if you use medications which reduce stomach acid or if you suffer from achlorhydria.
25-40% cure rate for fungal infections of the nails.Low cure rate, especially for toenail infections. Not approved by the FDA as a treatment for fungal infections of the toenails.

May interact with many other medications; especially antibiotics and medications used to treat asthma. Make sure your doctor has a complete list of medications which you are taking before starting to use this medication. The drug may cause life threatening cardiac problems if combined with certain types of medications. Do not use this medication if you have specific types of heart problems, including congestive heart failure, as life threatening reactions may occur.

May promote liver problems including hepatitis. Use caution if underlying liver disease is present. Monitor liver function tests during treatment. Notify your doctor if you experience severe abdominal pain, nausea or vomiting which does not go away, yellowing of the eyes or skin, or loss of appetite as rare, and possibly fatal reactions may occur.
Do not use if you have kidney disease. Use with caution if you have COPD. Be sure that your doctor is aware of your complete medical history if using this medication because it has harmful effects when certain illnesses are present.

Seek medical assistance if you experience: swelling of the face or throat, difficulty breathing or hives, swelling of the legs or feet, sudden tiredness, or weight gain.

May cause dizziness or drowsiness.

Older adults have an increased risk of hearing loss if this drug is used. Hearing loss may be temporary or permanent. Ringing in the ears may occur when this medication is employed.

Do not use if you plan to become pregnant, are pregnant, or are breastfeeding. Take measures to prevent conception for at least two months after discontinuing the use of this medication.

Notify your healthcare provider if you experience: a fever, persistent sore throat, changes in urination or sexual activity, hair loss, a fast or irregular heartbeat, depression, or enlarged breasts if you are male.
FluconazoleDiflucan(30) 150 mg generic tablets $8.00. Due to variable dosing regimens, cost may be more.Dosing schedules are variable.InexpensiveNot as effective as other antifungal agents used to treat nail infections.

May interact with other medications including, but not limited to, those used to treat seizure disorders and diabetes. The medicine may increase the risk of bleeding if used in conjunction with blood thinners. May interact with antibiotics.

Seek medical assistance if you experience: swelling of the face or throat, difficulty breathing or hives.

May cause dizziness, headache, rash changes in taste and digestive upsets.

Caution must be used if liver or kidney problems are present. May cause liver damage. White blood count cell and platelet levels may decrease when used.

Adverse reactions are more likely to occur if HIV infection is present.

A rash may occur. Notify your doctor if it does.
Complete Guide to Removing Nail Fungus

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The Global Nail Fungus Organization was founded with one goal: Fight Nail Fungus. We work towards this goal by providing resources, education, and solutions to the 35 million people currently suffering from finger and toenail fungus in America and the millions more around the world.