What is Nail Fungus?

Nail fungus, also known as Onychomycosis and often referred to as “Toenail Fungus” is a fungal infection of the toenails or fingernails. This difficult to cure condition causes nails to become thickened and discolored. Infected nails can turn white, black, yellow or green. The nail will often distort in shape and become brittle. If left untreated separation of the nail from the nail bed can occur. Nail fungus is an extremely common condition affecting about 20% of the global population. The condition is particularly difficult to eliminate due to the fact that the fungal infection is protected beneath the nail it inhabits. Nails, especially toenails, provide perfect growing conditions due to likelihood of moisture and a lack of air circulation. As you age, one becomes even more susceptible to nail fungus. The sooner you start to treat the fungus, the less entrenched it will become and the easier it will be to cure.

Three Treatment Methods

Surgical Removal
Surgical Removal
Oral Medication
Oral Medication
Topical Treatment
Topical Treatment

Problems with Scientific Research on the "Best Treatment" for Nail Fungus

Current research on therapies for fungal nail infections faces several challenges. One major issue is potential bias, particularly when studies are funded by pharmaceutical companies aiming to show their treatments are superior to competitors’. Researchers may be reluctant to publish negative results, compromising the integrity of the findings. Additionally, the quality of these studies can be poor, making it difficult to compare outcomes accurately. For example, one study might show a treatment as more effective simply because the participants were younger and healthier, leading to an unfair comparison akin to “comparing apples to oranges.”

Another issue is the inconsistent definition of “successful treatment.” One researcher might deem a treatment successful if the infection initially clears, even if it quickly recurs. In contrast, another researcher and the affected individual would likely view this as a failure. These discrepancies complicate the evaluation of treatment effectiveness and highlight the need for more standardized and unbiased research methodologies.

Our Approach to Explaining and Recommending Treatment

The Global Nail Fungus Organization was created to help the millions of people suffering from nail fungus find safe and effective treatment. We abide by the Hippocratic oath's principal of "first, do no harm" (primum non nocere). It is for this reason that we recommend nail fungus sufferers to first attempt over-the-counter topical treatments before exploring other available treatment options. Our research has found that alternatives to over-the-counter topical treatments come with elevated levels of risk or uncertainty – this includes the majority of prescription options, surgical options, and under-studied home remedies.

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Learn more about the different types of treatments available to nail fungus.

Treatment Types
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Learn how to use and maximize the effectiveness of over-the-counter topical treatments.

Treatment Guide
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Compare medications and determine which is best for you.

Medication Comparison
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